Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation
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چکیده
منابع مشابه
Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation
HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than HIV-1 bearing a single point mutation (N74D) in the capsid protein. We confirmed that digoxin rep...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2017
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1006460